Genetic characterization of measles viruses in China, 2004

Virol J. 2008 Oct 20:5:120. doi: 10.1186/1743-422X-5-120.

Abstract

Genetic characterization of wild-type measles virus was studied using nucleotide sequencing of the C-terminal region of the N protein gene and phylogenetic analysis on 59 isolates from 16 provinces of China in 2004. The results showed that all of the isolates belonged to genotype H1. 51 isolates were belonged to cluster 1 and 8 isolates were cluster 2 and Viruses from both clusters were distributed throughout China without distinct geographic pattern. The nucleotide sequence and predicted amino acid homologies of the 59 H1 strains were 96.5%-100% and 95.7%-100%, respectively. The report showed that the transmission pattern of genotype H1 viruses in China in 2004 was consistent with ongoing endemic transmission of multiple lineages of a single, endemic genotype. Multiple transmission pathways leaded to multiple lineages within endemic genotype.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • China / epidemiology
  • Cluster Analysis
  • Endemic Diseases
  • Humans
  • Measles / epidemiology*
  • Measles / transmission
  • Measles / virology*
  • Measles virus / classification*
  • Measles virus / genetics*
  • Measles virus / isolation & purification
  • Molecular Epidemiology
  • Molecular Sequence Data
  • Nucleocapsid Proteins
  • Nucleoproteins / genetics
  • Phylogeny
  • Sequence Analysis, DNA
  • Sequence Homology
  • Viral Proteins / genetics

Substances

  • Nucleocapsid Proteins
  • Nucleoproteins
  • Viral Proteins
  • nucleoprotein, Measles virus

Associated data

  • GENBANK/EU557194
  • GENBANK/EU557195
  • GENBANK/EU557196
  • GENBANK/EU557197
  • GENBANK/EU557198
  • GENBANK/EU557199
  • GENBANK/EU557200
  • GENBANK/EU557201
  • GENBANK/EU557202
  • GENBANK/EU557203
  • GENBANK/EU557204
  • GENBANK/EU557205
  • GENBANK/EU557206
  • GENBANK/EU557207
  • GENBANK/EU557208
  • GENBANK/EU557209
  • GENBANK/EU557210
  • GENBANK/EU557211
  • GENBANK/EU557212
  • GENBANK/EU557213
  • GENBANK/EU557214
  • GENBANK/EU557215
  • GENBANK/EU557216
  • GENBANK/EU557217
  • GENBANK/EU557218
  • GENBANK/EU557219
  • GENBANK/EU557220
  • GENBANK/EU557221
  • GENBANK/EU557222
  • GENBANK/EU557223
  • GENBANK/EU557224
  • GENBANK/EU557225
  • GENBANK/EU557226
  • GENBANK/EU557227
  • GENBANK/EU557228
  • GENBANK/EU557229
  • GENBANK/EU557230
  • GENBANK/EU557231
  • GENBANK/EU557232
  • GENBANK/EU557233
  • GENBANK/EU557234
  • GENBANK/EU557235
  • GENBANK/EU557236
  • GENBANK/EU557237
  • GENBANK/EU557238