Abstract
Here we review how mouse studies are contributing to understanding glaucoma. We include discussion of aqueous humor drainage and intraocular pressure elevation, because new treatments to avoid exposure to high pressure will indirectly protect neurons from glaucoma, and complement direct neuroprotective strategies. We describe how mouse models are adding to both the understanding of glaucomatous neurodegeneration and the development of neuroprotective strategies.
MeSH terms
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Animals
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Aqueous Humor
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Disease Models, Animal*
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Glaucoma* / pathology
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Glaucoma* / physiopathology
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Humans
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Intraocular Pressure
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Mice
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Mice, Inbred Strains
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Models, Genetic*
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Nerve Degeneration* / pathology
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Nerve Degeneration* / physiopathology
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Neuroprotective Agents
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Retinal Ganglion Cells / cytology
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Retinal Ganglion Cells / metabolism
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Tonometry, Ocular / methods
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Neuroprotective Agents
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Tumor Necrosis Factor-alpha