Abstract
Forty-five depressed patients were treated with imipramine for 6 weeks. Seven of 7 patients (100%) who had plasma levels of imipramine plus desipramine greater than 500 ng/ml showed a 50% or greater improvement in Hamilton depression scores compared with 23 of 38 patients (60%) with plasma levels less than 500 ng/ml (p less than 0.057).
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Depressive Disorder / blood*
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Depressive Disorder / drug therapy
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Depressive Disorder / psychology
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Desipramine / pharmacokinetics*
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Humans
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Imipramine / administration & dosage
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Imipramine / adverse effects
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Imipramine / pharmacokinetics*
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Male
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Psychiatric Status Rating Scales
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Psychometrics