Objective: To describe a unique case of recurrent aneuploidy and the use of preimplantation genetic screening (PGS).
Design: Case report.
Setting: Midwest academic medical center.
Patient(s): A 36-year-old woman with two trisomy 21 offspring.
Intervention(s): Preimplantation genetic screening.
Main outcome measure(s): Karyotype of embryos, liveborn eukaryotic infant.
Result(s): Preimplantation genetic screening was performed on three cryopreserved embryos, followed by a two-embryo transfer yielding a eukaryotic infant.
Conclusion(s): Preimplantation genetic screening may prove to be useful as a diagnostic tool to help ensure a euploid pregnancy when termination is not a viable option for a couple.