Abstract
Two new oleanane-type triterpene glycosides designated as Termiarjunoside I and Termiarjunoside II were isolated from stem bark of Terminalia arjuna (Combretaceae) and characterized as olean-1alpha,3beta,9alpha,22alpha-tetraol-12-en-28-oic acid-3beta-D-glucopyranoside (1) and olean-3alpha,5alpha,25-triol-12-en-23,28-dioic acid-3alpha-D-glucopyranoside (2) based on chemical and spectral data evidences. Both compounds 1 and 2 potently suppressed the release of nitric oxide and superoxide from macrophages and also inhibited aggregation of platelets.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Chromatography, High Pressure Liquid
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Glycosides / pharmacology
-
Humans
-
Macrophages / drug effects
-
Macrophages / enzymology
-
Macrophages / metabolism
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Oleanolic Acid / chemistry
-
Oleanolic Acid / isolation & purification*
-
Oleanolic Acid / pharmacology
-
Spectrometry, Mass, Electrospray Ionization
-
Spectrometry, Mass, Fast Atom Bombardment
-
Terminalia / chemistry*
Substances
-
Glycosides
-
Oleanolic Acid