Abstract
FBXW7 is reported to be a tumor suppressor gene, and the functional inactivation of FBXW7 has been reported in various human tumors. In this study, we investigated the FBXW7 gene in human thymoma; although no mutations were evident, a significantly high frequency of methylation in the FBXW7 beta-form promoter was observed in types B1 or higher (P=0.014). We propose a novel mechanism for the pathogenesis of thymoma by FBXW7 beta-form and hypothesize that expressional suppression plays an important role in the malignant potential of thymoma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Base Sequence
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Cell Cycle Proteins / genetics*
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DNA Methylation*
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DNA Mutational Analysis
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F-Box Proteins / genetics*
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F-Box-WD Repeat-Containing Protein 7
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Female
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Mutation
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Promoter Regions, Genetic
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Thymoma / classification
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Thymoma / genetics
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Thymoma / pathology*
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Thymus Neoplasms / classification
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Thymus Neoplasms / genetics
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Thymus Neoplasms / pathology*
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Tumor Suppressor Proteins / genetics*
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Ubiquitin-Protein Ligases / genetics*
Substances
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Cell Cycle Proteins
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F-Box Proteins
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F-Box-WD Repeat-Containing Protein 7
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FBXW7 protein, human
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Tumor Suppressor Proteins
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Ubiquitin-Protein Ligases