Hysterosalpingography (HSG) is a contrast investigation of the female reproductive tract. A major drawback to its use is pain during and after the procedure. This study was designed to evaluate the usefulness of Tramadol in alleviating the pain of the procedure and to assess the influence of tubal pathology on the degree of pain experienced. We studied 84 women; the patients were assigned randomly into two groups, group A and B. The first group, Group A (n=40) had premedication with intravenous Tramadol (100 mg) and IV hyoscine N butylbromide (20 mg), The Group B (n=44) had premedication with IV hyoscine N butylbromide (20 mg) only. The mean numeric rating pain score was 6.25 for the Tramadol group and 6.26 for the control group, P>0.05. This study does not show a significant decrease in pain perception during HSG in African women premedicated with Tramadol.