Abstract
Searching for new antiobesity agents, a new series of fatty acid amide derivatives of 1,5-diarylpyrazole have been synthesized as dual peroxisome proliferator activated receptor alpha (PPARalpha)/cannabinoid receptor ligands. The compounds have been evaluated in vivo and in vitro as PPARalpha activators and as cannabinoids in two tests of the mouse tetrad. In vivo, food intake studies have been performed with all the compounds. No significant cannabinoid activity has been found but some compounds behaved as potent PPARalpha activators. Several compounds showed anorexigenic properties reducing food intake in rats.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis
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Amides / chemistry
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Amides / pharmacology
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Animals
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Anti-Obesity Agents / chemical synthesis*
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Anti-Obesity Agents / chemistry
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Anti-Obesity Agents / pharmacology*
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Cannabinoids / chemistry
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Cannabinoids / metabolism
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Eating
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Fatty Acids / chemical synthesis
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Fatty Acids / chemistry*
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Fatty Acids / pharmacology
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Glutathione Transferase / metabolism
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Mice
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PPAR alpha / agonists*
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PPAR alpha / metabolism
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
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Rats
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Rats, Wistar
Substances
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Amides
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Anti-Obesity Agents
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Cannabinoids
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Fatty Acids
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PPAR alpha
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Pyrazoles
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Glutathione Transferase