Enantiomerically pure bicyclo[3.3.1]nona-2,6-diene as the sole source of enantioselectivity in BIPHEP-Rh asymmetric hydrogenation

Tharmalingam Punniyamurthy; Monika Mayr; Alexander S Dorofeev; Carole J R Bataille; Silvia Gosiewska; Bao Nguyen; Andrew R Cowley; John M Brown

doi:10.1039/b807669c

Enantiomerically pure bicyclo[3.3.1]nona-2,6-diene as the sole source of enantioselectivity in BIPHEP-Rh asymmetric hydrogenation

Chem Commun (Camb). 2008 Nov 7:(41):5092-4. doi: 10.1039/b807669c. Epub 2008 Sep 12.

Authors

Tharmalingam Punniyamurthy¹, Monika Mayr, Alexander S Dorofeev, Carole J R Bataille, Silvia Gosiewska, Bao Nguyen, Andrew R Cowley, John M Brown

Affiliation

¹ Chemical Research Laboratory, 12 Mansfield Rd, Oxford, UKOX1 3TA. [email protected]

PMID: 18956032
DOI: 10.1039/b807669c

Abstract

In situ resolution of the rapidly racemising diphosphine BIPHEP and its relatives with the cationic Rh complex of (S,S)-bicyclonona-2,6-diene permits the asymmetric hydrogenation of dehydroamino esters.