Abstract
The Doublesex (DSX) transcription factor regulates somatic sexual differentiation in Drosophila melanogaster. Female and male isoforms (DSXF and DSXM) are produced due to sex-specific RNA splicing. Here we show that in the distantly related dipteran Ceratitis capitata, the DSXM male-specific isoform is conserved and able to induce masculinization of both somatic and germline tissues when ectopically expressed in XX Drosophila transgenic individuals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3' Untranslated Regions
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Amino Acid Sequence
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Animals
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Animals, Genetically Modified
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Base Sequence
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Binding Sites / genetics
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Ceratitis capitata / genetics*
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Cloning, Molecular
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DNA Primers / genetics
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DNA-Binding Proteins / genetics*
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Drosophila Proteins / genetics*
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Drosophila melanogaster / genetics*
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Drosophila melanogaster / growth & development*
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Female
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Genes, Insect
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Insect Proteins / genetics*
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Male
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Molecular Sequence Data
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Phenotype
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Protein Isoforms / genetics
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Sequence Homology, Amino Acid
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Sex Differentiation / genetics
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Species Specificity
Substances
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3' Untranslated Regions
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DNA Primers
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DNA-Binding Proteins
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DSX protein, Drosophila
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Drosophila Proteins
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Insect Proteins
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Protein Isoforms