Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease

J Biol Chem. 2009 Feb 20;284(8):4755-9. doi: 10.1074/jbc.R800018200. Epub 2008 Oct 28.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Brain / metabolism*
  • Brain / pathology
  • Humans
  • Mutation*
  • Presenilin-1 / genetics
  • Presenilin-1 / metabolism
  • Presenilin-2 / genetics
  • Presenilin-2 / metabolism

Substances

  • Amyloid beta-Peptides
  • PSEN2 protein, human
  • Presenilin-1
  • Presenilin-2