Abstract
Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Actins / drug effects
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Actins / metabolism*
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Division / drug effects
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Cucurbitacins / chemistry
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Cucurbitacins / isolation & purification
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Cucurbitacins / pharmacology*
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Cytokinesis / drug effects
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Drosophila
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Rosaceae / chemistry*
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Triterpenes
Substances
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Actins
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Antineoplastic Agents, Phytogenic
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Triterpenes
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dihydrocucurbitacin F
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cucurbitacin F
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Cucurbitacins