Abstract
We used an in vivo rat model to demonstrate that low-dose intradermal exposure to E(2) valerate has an inverse effect on the female's estrus cycle pattern and can significantly reduce litter size. These results suggest that, under certain circumstances, environmental exposure to exogenous estrogens may play a role as an endocrine disruptor and adversely affect reproductive outcome.
MeSH terms
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Animals
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Contraceptive Agents / administration & dosage
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Contraceptive Agents / pharmacology*
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Dose-Response Relationship, Drug
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Environmental Exposure / adverse effects
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Estradiol / administration & dosage
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Estradiol / analogs & derivatives*
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Estradiol / pharmacology
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Estrus / drug effects*
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Estrus / physiology
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Female
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Injections, Intradermal
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Litter Size / drug effects
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Models, Animal
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Rats
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Rats, Inbred WKY
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Reproduction / drug effects*
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Reproduction / physiology
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Skin / immunology
Substances
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Contraceptive Agents
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Estradiol