Grignard cross-coupling amenable to large scale production of alpha-fluorostyryl and alpha-fluorovinylthiophenes

J Org Chem. 2008 Dec 19;73(24):9775-7. doi: 10.1021/jo801647x.

Abstract

An efficient nickel-catalyzed Kumada-Corriu cross coupling enabled the introduction of an alpha-fluorovinyl functionality with excellent conversion and specificity.

MeSH terms

  • Catalysis
  • Chromatography, High Pressure Liquid
  • Crystallization
  • Indicators and Reagents
  • Nickel / chemistry
  • Temperature
  • Thiophenes / chemical synthesis*
  • Vinyl Compounds / chemical synthesis*

Substances

  • Indicators and Reagents
  • Thiophenes
  • Vinyl Compounds
  • Nickel