Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis

I S Lee; K Y Jung; S R Oh; D S Kim; J H Kim; J J Lee; H K Lee; S H Lee; E H Kim; C Cheong

doi:10.1007/BF02975223

Platelet-activating factor antagonistic activity and(13)C NMR assignment of pregomisin and chamigrenal fromSchisandra chinensis

Arch Pharm Res. 1997 Dec;20(6):633-6. doi: 10.1007/BF02975223.

Authors

I S Lee¹, K Y Jung, S R Oh, D S Kim, J H Kim, J J Lee, H K Lee, S H Lee, E H Kim, C Cheong

Affiliation

¹ Natural Product Biosynthesis Research Unit, Korea Research Institute of Bioscience & Biotechnology, Yusong, P.O. Box 115, 305-600, Taejon, Korea.

PMID: 18982271
DOI: 10.1007/BF02975223

Abstract

In the course of searching for PAF receptor antagonists, pregomisin (1) and chamigrenal (2) were isolated from the fruits ofSchizandra chinensis Baill by the bioactivity-guided isolation. Both compounds showed PAF antagonistic activity and the IC(50) values were 4.8x10(-5) M and 1.2x10(-4) M, respectively. In addition, the(13)C NMR assignments of1 and2 using DEPT, HMQC, COLOC and HMBC were reported for the first time.