A new cytotoxic guaianolide from Chrysanthemum boreale

Ki Hun Park; Min Suk Yang; Moon Ki Park; Sang Chan Kim; Chae Ha Yang; Sook Jahr Park; Jong Rok Lee

doi:10.1016/j.fitote.2008.09.013

A new cytotoxic guaianolide from Chrysanthemum boreale

Fitoterapia. 2009 Jan;80(1):54-6. doi: 10.1016/j.fitote.2008.09.013. Epub 2008 Oct 14.

Authors

Ki Hun Park¹, Min Suk Yang, Moon Ki Park, Sang Chan Kim, Chae Ha Yang, Sook Jahr Park, Jong Rok Lee

Affiliation

¹ Division of Applied Life Science (BK21 program), EB-NCRC, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 660-701, Republic of Korea.

PMID: 18983901
DOI: 10.1016/j.fitote.2008.09.013

Abstract

A new cytotoxic guaianolide was isolated from Chrysanthemum boreale Makino. The structure of guaianolide was elucidated as 8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide (1). Compound 1 exhibited cytotoxic activity (IC(50)< or =4 microg/ml) against all five human cancer cell lines tested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / therapeutic use*
Cell Line, Tumor
Chrysanthemum / chemistry*
Cytotoxins / chemistry
Cytotoxins / isolation & purification
Cytotoxins / therapeutic use*
Humans
Molecular Structure
Neoplasms / drug therapy*
Phytotherapy*
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / therapeutic use*
Plant Leaves / chemistry
Plant Stems / chemistry
Sesquiterpenes, Guaiane / chemistry
Sesquiterpenes, Guaiane / isolation & purification
Sesquiterpenes, Guaiane / therapeutic use*

Substances

8-acetoxy-4,10-dihydroxy-2,11(13)-guaiadiene-12,6-olide
Antineoplastic Agents, Phytogenic
Cytotoxins
Plant Extracts
Sesquiterpenes, Guaiane