Abstract
Stem cell self-renewal capacity declines with age. In a recent issue of Cell, Nishino and colleagues (2008) show that Hmga2 maintains neural stem cell (NSC) function in young mice through repression of the Ink4a/Arf locus; in contrast, during aging, elevated let-7b blocks Hmga2 and contributes to declining NSC function.
Publication types
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Introductory Journal Article
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Comment
MeSH terms
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Aging
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Animals
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Cell Differentiation / genetics
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Cell Proliferation
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Cellular Senescence / genetics*
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Cyclin-Dependent Kinase Inhibitor p16 / genetics*
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Cyclin-Dependent Kinase Inhibitor p16 / metabolism
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Gene Expression Regulation, Developmental
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HMGA2 Protein / antagonists & inhibitors
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HMGA2 Protein / genetics*
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Homeostasis / genetics
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Humans
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Mice
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MicroRNAs / biosynthesis
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MicroRNAs / genetics*
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Neurons / cytology
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Neurons / metabolism*
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Stem Cells / cytology
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Stem Cells / physiology*
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Transcriptional Activation
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Tumor Suppressor Protein p14ARF / genetics*
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Tumor Suppressor Protein p14ARF / metabolism
Substances
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Cyclin-Dependent Kinase Inhibitor p16
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HMGA2 Protein
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MicroRNAs
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Tumor Suppressor Protein p14ARF
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mirnlet7 microRNA, human