Late angiographic stent thrombosis after Cyphertrade mark stent implantation has been reported to occur till approximately one year after the procedure and usually soon after the discontinuation of all antiplatelet medication.We report a case of very late stent thrombosis occurring 27 months (790 days) after stent implantation and 13 months after clopidogrel discontinuation despite being on regular aspirin. This case underlines the possible need for long-term dual antiplatelet therapy after implantation of drug-eluting stents.