Enantioselective synthesis of cyclopropylcarboxamides using s-BuLi-sparteine-mediated metallation

Chem Commun (Camb). 2008 Nov 14:(42):5390-2. doi: 10.1039/b810441g. Epub 2008 Sep 16.

Abstract

Enantioselective synthesis of cyclopropylcarboxamides is possible by asymmetric metallation of prochiral starting cyclopropanes using s-BuLi-sparteine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Catalysis
  • Crystallography, X-Ray
  • Cyclopropanes / chemistry*
  • Lithium / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Sparteine / chemistry*
  • Stereoisomerism

Substances

  • Amides
  • Cyclopropanes
  • Sparteine
  • Lithium