Design, synthesis, bioactivity, and structure-activity relationship (SAR) studies of novel benzoylphenylureas containing oxime ether group

J Agric Food Chem. 2008 Dec 10;56(23):11376-91. doi: 10.1021/jf801901h.

Abstract

Novel benzoylphenylureas containing an oxime ether group were designed and synthesized by four schemes. These benzoylphenylureas were identified by (1)H NMR spectroscopy and element analysis (or HRMS). The bioactivities of the new compounds were evaluated. These benzoylphenylureas exhibited excellent larvicidal activities against oriental armyworm, some of which were much better in comparison with the commercial Flucycloxuron. In particular, the larvicidal activities against oriental armyworm of compounds 1 and 23 were 5-10 times better than that of Flucycloxuron. Most of these benzoylphenyureas exhibited excellent larvicidal activities against mosquito. At the same time, some of these compounds have good plant growth regulatory activities as well.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Culicidae / drug effects
  • Drug Design*
  • Ethers / chemistry
  • Insecticides / chemical synthesis
  • Insecticides / chemistry*
  • Insecticides / pharmacology*
  • Larva / drug effects
  • Molecular Structure
  • Moths / drug effects
  • Oximes / chemistry
  • Phenylurea Compounds / chemical synthesis*
  • Phenylurea Compounds / chemistry
  • Phenylurea Compounds / pharmacology*
  • Structure-Activity Relationship

Substances

  • Ethers
  • Insecticides
  • Oximes
  • Phenylurea Compounds