Abstract
The beta-subunit (G-beta) of the squid (Loligo forbesi) visual GTP-binding protein (G-protein), thought to be associated with a phosphatidylinositol-specific phospholipase C, has been identified and the sequence of the protein determined from its cDNA. The predicted polypeptide has a very marked sequence similarity with its mammalian counterparts (80-90% identity). Squid G-beta also has somewhat lower similarity to the yeast protein STE4 (approx. 40% identity). The role of G-beta in signal transduction is discussed in the light of its pronounced structural conservation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cattle
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DNA / genetics
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Decapodiformes
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Drosophila / genetics
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Electrophoresis, Polyacrylamide Gel
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GTP-Binding Proteins / genetics*
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Humans
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Molecular Sequence Data
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Phosphatidylinositols / metabolism*
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Photoreceptor Cells / metabolism*
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Saccharomyces cerevisiae / genetics
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Sequence Homology, Nucleic Acid
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Type C Phospholipases / metabolism*
Substances
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Phosphatidylinositols
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DNA
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Type C Phospholipases
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GTP-Binding Proteins
Associated data
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GENBANK/M64055
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GENBANK/M64056
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GENBANK/M64057
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GENBANK/M64058
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GENBANK/M64059
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GENBANK/M64060
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GENBANK/M83107
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GENBANK/S67100
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GENBANK/S78039
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GENBANK/X56757