Abstract
Using a DNA microarray, we found that expression of the genes related to lactate metabolism was upregulated in a lactate-producing recombinant Saccharomyces cerevisiae strain. Disruption of the CYB2 gene encoding L-lactate dehydrogenase improved the L-lactate production by S. cerevisiae under low pH condition.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Genetic Engineering*
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Humans
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Hydrogen-Ion Concentration
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L-Lactate Dehydrogenase / genetics*
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L-Lactate Dehydrogenase / metabolism
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Lactic Acid / biosynthesis*
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / metabolism*
Substances
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Lactic Acid
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L-Lactate Dehydrogenase