Abstract
Objective:
To study the cytotoxicity of the secondary metabolites of Marine Mangrove Fungus Paecilomyces sp. Tree 1-7 on human hepatoma cell line HepG2 cultured in vitro.
Methods:
Three groups were divided: compounds group, 5-Fu group and control group. The cytotoxicity was measured by MTT method when HepG2 cells were treated by different concentration of the secondary metabolites of Paecilomyces sp. Tree 1-7.
Results:
Secalonic acid A, tenellic acid A and alternin inhibited the growth of human hepatoma cell line HepG2, the IC50 separately were 2.0, 62.1 and 7.0 microg/ml.
Conclusion:
Secalonic acid A and alternin have strong cytotoxicity on HepG2 cultured in vitro.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology*
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Benzoates / chemistry
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Benzoates / isolation & purification
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Benzoates / pharmacology*
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Carcinoma, Hepatocellular / pathology
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Cell Line, Tumor
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Fluorouracil / pharmacology
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Humans
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Inhibitory Concentration 50
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Liver Neoplasms / pathology
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Paecilomyces / chemistry*
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Paecilomyces / metabolism
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Phenyl Ethers / chemistry
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Phenyl Ethers / isolation & purification
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Phenyl Ethers / pharmacology*
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Rhizophoraceae / microbiology*
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Xanthones / chemistry
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Xanthones / isolation & purification
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Xanthones / pharmacology*
Substances
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Antineoplastic Agents
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Benzoates
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Phenyl Ethers
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Xanthones
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methyl 3-(1-acetoxy-3-methylbutyl)-2-methoxy-6-(2- methoxy-4-methyl-6-(2-oxopropyl)phenoxy)benzoate
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secalonic acid
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Fluorouracil