Abstract
Aspirin hypersensitivity syndrome includes several symptoms from the respiratory tract, skin and digestive system triggered by ingestion of aspirin or other nonsteroidal anti-inflammatory drugs. Asthmatic attacks precipitated by aspirin or other nonsteroidal anti-inflammatory drugs occur in about 10% of all asthmatic patients. In subjects with aspirin hypersensitivity disruption of synthesis of prostaglandin E2 (PGE2) and overproduction of cysteinyl leukotrienes (Cys-LT) seem to be crucial in the pathogenesis of bronchial symptoms. Double blind, placebo controlled challenges are regarded as a gold standard in the diagnosis of aspirin hypersensitivity.
MeSH terms
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Allergens / administration & dosage
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Allergens / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Aspirin / administration & dosage
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Aspirin / adverse effects*
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Asthma / chemically induced*
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Asthma / diagnosis*
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Asthma / metabolism
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Asthma / prevention & control
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Dinoprostone / metabolism
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Drug Hypersensitivity / diagnosis*
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Drug Hypersensitivity / etiology*
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Drug Hypersensitivity / metabolism
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Drug Hypersensitivity / prevention & control
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Humans
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Receptors, Leukotriene / metabolism
Substances
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Allergens
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Anti-Inflammatory Agents, Non-Steroidal
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Receptors, Leukotriene
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Dinoprostone
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Aspirin