The new blood vessels formation in the body is through vasculogenesis, angiogenesis, lymphangiogenesis and arteriogenesis processes. A process of creating new blood vessels is necessary for normal organism function, and is necessary too in pathogenesis of many diseases and disorders like inflammatory or malignancies. Vascular-Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (bFGF) are the main stimulators blood vessels formation. Knowledge about properties and function these markers can be used in diagnosis and treatment of diseases like malignancies. These article is summary knowledge about structure and function VEGF and bFGF.