An innate path to human B cell tolerance

Immunity. 2008 Nov 14;29(5):667-9. doi: 10.1016/j.immuni.2008.10.001.

Abstract

Self-reactive B cells are eliminated during development by antibody-affinity selection and receptor-editing mechanisms. Work by Isnardi et al. (2008) in this issue of Immunity suggests that removal of autoreactivity from the immature B cell pool also requires innate immunity pathways.

Publication types

  • Comment

MeSH terms

  • Autoimmunity / genetics
  • Autoimmunity / immunology*
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / metabolism
  • Cell Differentiation
  • Clonal Deletion
  • Humans
  • Immunity, Innate*
  • Interleukin-1 Receptor-Associated Kinases / deficiency
  • Interleukin-1 Receptor-Associated Kinases / metabolism
  • Myeloid Differentiation Factor 88 / deficiency
  • Myeloid Differentiation Factor 88 / metabolism
  • Self Tolerance / immunology*
  • Toll-Like Receptors / immunology
  • Toll-Like Receptors / metabolism

Substances

  • MYD88 protein, human
  • Myeloid Differentiation Factor 88
  • Toll-Like Receptors
  • IRAK4 protein, human
  • Interleukin-1 Receptor-Associated Kinases