Abstract
Ainsliatrimers A (1) and B (2), the first two guaianolide-type sesquiterpene lactone trimers, together with one new structurally related sesquiterpene dimer ainsliadimer B (3), were isolated from the aerial part of Ainsliaea fulvioides. Their structures were elucidated by spectroscopic techniques, including X-ray crystal diffraction. Both 1 and 2 showed potent cytotoxicites against LOVO and CEM cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Asteraceae / chemistry*
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Asteraceae / metabolism
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Humans
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Molecular Conformation
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Plant Components, Aerial / chemistry
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Plant Components, Aerial / metabolism
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Sesquiterpenes, Guaiane / chemistry*
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Sesquiterpenes, Guaiane / isolation & purification
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Sesquiterpenes, Guaiane / pharmacology
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X-Ray Diffraction
Substances
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Antineoplastic Agents, Phytogenic
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Sesquiterpenes, Guaiane
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ainsliatrimer A
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ainsliatrimer B