Abstract
Hyperbranched polyglycerols (HPGs) are ideal scaffolds for the multivalent presentation of saccharides, due to their biocompatible, carbohydrate-like properties; here, we report the conjugation of galactosesugar moieties to HPG, and the multivalent effect of these constructs on selectin binding.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocompatible Materials / chemical synthesis*
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Biocompatible Materials / chemistry
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E-Selectin / metabolism
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Galactose / chemistry*
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Glycerol / chemistry*
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L-Selectin / metabolism
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P-Selectin / antagonists & inhibitors
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P-Selectin / metabolism
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Polymers / chemistry*
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Protein Binding
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Selectins / metabolism*
Substances
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Biocompatible Materials
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E-Selectin
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P-Selectin
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Polymers
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Selectins
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L-Selectin
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polyglycerol
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Glycerol
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Galactose