Abstract
Loss of Abf2p, an abundant mitochondrial nucleoid-associated protein, results in increased mitochondrial frameshifts and direct-repeat mediated deletions but has no effect on the rate of mitochondrial point mutations. The instability of repeated sequences in this strain may be linked to the loss of mitochondrial DNA in abf2-Delta strains.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aerobiosis / radiation effects
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DNA, Mitochondrial / genetics*
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DNA-Binding Proteins / deficiency*
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DNA-Binding Proteins / metabolism
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Genes, Reporter
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Genome, Mitochondrial / genetics*
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Genomic Instability* / radiation effects
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Microbial Viability / radiation effects
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Mutation / genetics
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Repetitive Sequences, Nucleic Acid / genetics*
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / radiation effects
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Saccharomyces cerevisiae Proteins / metabolism
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Transcription Factors / deficiency*
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Transcription Factors / metabolism
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Ultraviolet Rays
Substances
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ABF2 protein, S cerevisiae
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DNA, Mitochondrial
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DNA-Binding Proteins
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Saccharomyces cerevisiae Proteins
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Transcription Factors