Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin

Rishi G Vaswani; Agenor Limon; Jorge Mauricio Reyes-Ruiz; Ricardo Miledi; A Richard Chamberlin

doi:10.1016/j.bmcl.2008.11.004

Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-kaitocephalin

Bioorg Med Chem Lett. 2009 Jan 1;19(1):132-5. doi: 10.1016/j.bmcl.2008.11.004. Epub 2008 Nov 6.

Authors

Rishi G Vaswani¹, Agenor Limon, Jorge Mauricio Reyes-Ruiz, Ricardo Miledi, A Richard Chamberlin

Affiliation

¹ Department of Chemistry, University of California at Irvine, Irvine, CA 92697, USA.

PMID: 19017555
DOI: 10.1016/j.bmcl.2008.11.004

Abstract

The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (-)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Drug Design
Excitatory Amino Acid Agonists / chemistry
Excitatory Amino Acid Antagonists / chemistry
Humans
Ligands
Pyrroles / chemistry*
Pyrrolidines / chemical synthesis*
Pyrrolidines / pharmacology
Receptors, Glutamate / drug effects*
Structure-Activity Relationship

Substances

Excitatory Amino Acid Agonists
Excitatory Amino Acid Antagonists
Ligands
Pyrroles
Pyrrolidines
Receptors, Glutamate
kaitocephalin

Abstract

Publication types

MeSH terms

Substances

Grants and funding