Scalarane-based metabolites isolated from the antimitotic extract of the marine sponge Hyrtios erectus

Ana R Díaz-Marrero; Teatulohi Matainaho; Rob van Soest; Michel Roberge; Raymond J Andersen

doi:10.1080/14786410701824023

Scalarane-based metabolites isolated from the antimitotic extract of the marine sponge Hyrtios erectus

Nat Prod Res. 2008;22(15):1304-9. doi: 10.1080/14786410701824023.

Authors

Ana R Díaz-Marrero¹, Teatulohi Matainaho, Rob van Soest, Michel Roberge, Raymond J Andersen

Affiliation

¹ Department of Chemistry, University of British Columbia, Vancouver, Canada.

PMID: 19023786
DOI: 10.1080/14786410701824023

Abstract

Two novel sesterterpenes, 1 and 3, containing a scalarane-based framework, have been isolated from the sponge Hyrtios erectus collected in Papua New Guinea. Their structures and relative stereochemistry have been elucidated by analysis of their spectroscopic data.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimitotic Agents* / chemistry
Antimitotic Agents* / isolation & purification
Antimitotic Agents* / pharmacology
Female
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Papua New Guinea
Porifera / chemistry*
Sesterterpenes* / chemistry
Sesterterpenes* / isolation & purification
Sesterterpenes* / pharmacology
Stereoisomerism

Substances

12-O-deacetyl-12-epi-scalarin
12-O-deacetyl-19-methoxy-12-epi-scalarin
12beta,16beta-diacetoxyscalarolbutenolide
Antimitotic Agents
Sesterterpenes