Abstract
Histoplasma polysaccharide antigen testing is used routinely to diagnose histoplasmosis. At least 3 antigen tests are commercially available. Controversy exists about the relative accuracy of these tests. We report 2 patients with AIDS and culture-confirmed Histoplasma capsulatum meningitis from whom discrepant Histoplasma polysaccharide antigen results were obtained from different laboratories and discuss the potential clinical implications of these results.
MeSH terms
-
Acquired Immunodeficiency Syndrome / complications*
-
Adult
-
Amphotericin B / therapeutic use
-
Antifungal Agents / therapeutic use
-
Antigens, Fungal / urine*
-
Diagnostic Errors
-
Histoplasma / isolation & purification
-
Histoplasmosis / complications
-
Histoplasmosis / diagnosis*
-
Histoplasmosis / drug therapy
-
Humans
-
Immunoenzyme Techniques / methods
-
Immunoenzyme Techniques / standards
-
Laboratories / standards
-
Male
-
Meningitis, Fungal / complications
-
Meningitis, Fungal / diagnosis*
-
Meningitis, Fungal / drug therapy
-
Polysaccharides / urine
-
Reproducibility of Results
-
Sensitivity and Specificity
Substances
-
Antifungal Agents
-
Antigens, Fungal
-
Polysaccharides
-
liposomal amphotericin B
-
Amphotericin B