Caspases and IAPs: a dance of death ensures cell survival

Mol Cell. 2008 Nov 21;32(4):462-3. doi: 10.1016/j.molcel.2008.11.005.

Abstract

In this issue of Molecular Cell, Ditzel et al. (2008) show that DIAP1 polyubiquitinates DRONC, DCP-1, and drICE, leading to their nondegradative inactivation. Surprisingly, activation of DIAP1 requires caspase-mediated cleavage, revealing an elegant feedback mechanism by which caspases regulate their own fate.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Apoptosis / physiology*
  • Caspases / genetics
  • Caspases / metabolism*
  • Cell Survival
  • Drosophila / cytology
  • Drosophila / genetics
  • Drosophila / metabolism
  • Feedback, Physiological
  • Inhibitor of Apoptosis Proteins / genetics
  • Inhibitor of Apoptosis Proteins / metabolism*
  • Models, Biological
  • Ubiquitination

Substances

  • Inhibitor of Apoptosis Proteins
  • Caspases