General method for the synthesis of phenyliodonium ylides from malonate esters: easy access to 1,1-cyclopropane diesters

J Org Chem. 2009 Jan 2;74(1):470-3. doi: 10.1021/jo802208q.

Abstract

A general method to access phenyliodonium ylides from malonates has been developed. These ylides provide easy access to a variety of useful 1,1-cyclopropane diesters using rhodium or copper catalysis. Moreover, the iodonium ylide of dimethyl malonate was obtained in 78% yield using improved conditions that involve a simple filtration step to isolate the desired product. This ylide was shown to be a safer and convenient alternative to the corresponding diazo compound and a very efficient way to 1,1-cyclopropane diesters when used with a catalytic amount of Rh(2)(esp)(2).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclopropanes / chemical synthesis*
  • Cyclopropanes / chemistry
  • Esters / chemical synthesis*
  • Esters / chemistry*
  • Malonates / chemistry*
  • Molecular Structure
  • Onium Compounds / chemical synthesis*
  • Onium Compounds / chemistry
  • Stereoisomerism

Substances

  • Cyclopropanes
  • Esters
  • Malonates
  • Onium Compounds
  • phenyliodonium