Abstract
A novel domino reaction based on o-phthalaldehyde and 3-oxo-N-arylbutanamide 1 has been developed which allows one-pot and efficient synthesis of structurally complex spiroindan-2,2'-pyrrolidines 2 and 3 with complete regioselectivity and high stereoselectivity from acyclic precursors.
MeSH terms
-
Acetamides / chemistry*
-
Aldehydes / chemistry*
-
Aza Compounds / chemistry*
-
Crystallography, X-Ray
-
Cyclization
-
Ketones / chemistry*
-
Magnetic Resonance Spectroscopy
-
Models, Molecular
-
Molecular Structure
-
Pyrrolidines / chemical synthesis*
-
Pyrrolidines / chemistry
-
Spiro Compounds / chemical synthesis*
-
Spiro Compounds / chemistry
-
Stereoisomerism
Substances
-
Acetamides
-
Aldehydes
-
Aza Compounds
-
Ketones
-
Pyrrolidines
-
Spiro Compounds