Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida

Biswanath Das; Kongara Ravinder Reddy; Bommena Ravikanth; Tuniki Venugopal Raju; Balasubramanian Sridhar; Patan Usman Khan; Janapala Venkateswara Rao

doi:10.1016/j.bmcl.2008.11.014

Multifidone: a novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida

Bioorg Med Chem Lett. 2009 Jan 1;19(1):77-9. doi: 10.1016/j.bmcl.2008.11.014. Epub 2008 Nov 9.

Authors

Biswanath Das¹, Kongara Ravinder Reddy, Bommena Ravikanth, Tuniki Venugopal Raju, Balasubramanian Sridhar, Patan Usman Khan, Janapala Venkateswara Rao

Affiliation

¹ Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad, India. [email protected]

PMID: 19036584
DOI: 10.1016/j.bmcl.2008.11.014

Abstract

Chemical examination of the stems of Jatropha multifida afforded a novel lathyrane-type diterpene, multifidone, having an unusual six-membered A ring. The structure of the compound was determined from detailed analysis of its 1D and 2D NMR spectra and X-ray crystallographic analysis. Its cytotoxicity was measured on four different cancerous cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Cell Line, Tumor
Crystallography, X-Ray
Diterpenes / chemistry*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Humans
Jatropha / chemistry*
Magnetic Resonance Spectroscopy
Molecular Structure

Substances

Antineoplastic Agents, Phytogenic
Diterpenes
lathyrane