Abstract
The 80% aqueous acetone extract from the flowers of Hedychium coronarium was found to show a protective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. On the other hand, two new labdane-type diterpene glycosides, coronalactosides I (1) and II (2), and a new labdane-type trinorditerpene, coronadiene (3), were isolated together with 8 known compounds from the extracts, which were obtained with chloroform and 80% aqueous acetone from the flowers of H. coronarium. The structures of new constituents were elucidated on the basis of chemical and physicochemical evidence. In addition, the principal constituents, coronaririn C and 15-hydroxylabda-8(17),11,13-trien-16,15-olide, displayed hepatoprotective effects, which were stronger than that of the hepatoprotective agent, silybin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetone
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Animals
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Cell Survival / drug effects
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Chemical and Drug Induced Liver Injury / prevention & control*
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Diterpenes / chemistry*
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Diterpenes / isolation & purification*
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Flowers / chemistry
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Hepatocytes / drug effects
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Hydrolysis
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Male
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Mice
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Molecular Conformation
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Multienzyme Complexes / chemistry
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Plant Extracts / chemistry
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Plants, Medicinal / chemistry*
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Protective Agents / isolation & purification
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Protective Agents / pharmacology*
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Silybin
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Silymarin / pharmacology
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Solvents
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectroscopy, Fourier Transform Infrared
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Zingiberaceae / chemistry*
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beta-Glucosidase / chemistry
Substances
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Diterpenes
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Multienzyme Complexes
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Plant Extracts
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Protective Agents
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Silymarin
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Solvents
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coronadiene
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coronalactoside I
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coronalactoside II
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Acetone
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Silybin
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naringinase
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beta-Glucosidase