Abstract
Known and potential aspirin metabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-alpha in cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aspirin / chemistry*
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Aspirin / metabolism
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Aspirin / pharmacology*
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Dioxygenases / metabolism*
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology*
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Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors*
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
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Molecular Structure
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Spectrometry, Mass, Electrospray Ionization
Substances
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Enzyme Inhibitors
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Hypoxia-Inducible Factor 1, alpha Subunit
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Dioxygenases
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Aspirin