Newcastle disease virus in West Africa: new virulent strains identified in non-commercial farms

Chantal J Snoeck; Mariette F Ducatez; Ademola A Owoade; Olufemi O Faleke; Bello R Alkali; Marc C Tahita; Zekiba Tarnagda; Jean-Bosco Ouedraogo; Issoufou Maikano; Patrick Okwen Mbah; Jacques R Kremer; Claude P Muller

doi:10.1007/s00705-008-0269-5

Newcastle disease virus in West Africa: new virulent strains identified in non-commercial farms

Arch Virol. 2009;154(1):47-54. doi: 10.1007/s00705-008-0269-5. Epub 2008 Dec 4.

Authors

Chantal J Snoeck¹, Mariette F Ducatez, Ademola A Owoade, Olufemi O Faleke, Bello R Alkali, Marc C Tahita, Zekiba Tarnagda, Jean-Bosco Ouedraogo, Issoufou Maikano, Patrick Okwen Mbah, Jacques R Kremer, Claude P Muller

Affiliation

¹ National Public Health Laboratory, Institute of Immunology, 20A rue Auguste Lumière, 1950, Luxembourg, Luxembourg.

PMID: 19052688
DOI: 10.1007/s00705-008-0269-5

Abstract

Forty-four Newcastle disease virus (NDV) strains, obtained between 2002 and 2007 from different poultry species in Nigeria, Niger, Burkina Faso and Cameroon, were phylogenetically analysed based on partial F sequences. Lineage 2 viruses were genetically identical or similar to the locally used LaSota vaccine strain and were mostly detected in commercial farms. Lineage 1, 3 and 4 strains were only sporadically found, and their origin was less clear. Twenty-one strains from backyard farms and live bird markets formed three new clusters within lineage 5, tentatively named 5f, 5g and 5h. All of these strains were predicted to be virulent based on their F protein cleavage site sequence. Minimal genetic distances between new and previously established sublineages ranged from 9.4 to 15.9%, and minimal distances between the new sublineages were 11.5 to 17.3%. Their high genetic diversity and their presence in three different Sub-Saharan countries suggest that these new sublineages represent the NDV variants indigenous to West Africa.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Africa South of the Sahara / epidemiology
Amino Acid Sequence
Animals
Chickens
Molecular Sequence Data
Newcastle Disease / virology*
Newcastle disease virus / classification*
Newcastle disease virus / genetics
Newcastle disease virus / isolation & purification
Newcastle disease virus / pathogenicity
Phylogeny
Poultry Diseases / virology*
Viral Fusion Proteins / genetics

Substances

Viral Fusion Proteins

Associated data

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