Platinum-catalyzed cycloisomerization reaction of 1,6-enyne coupling with rearrangement of propargylic esters

J Org Chem. 2009 Jan 2;74(1):474-7. doi: 10.1021/jo802043z.

Abstract

A platinum-catalyzed cycloisomerization of 1,6-enyne coupling with the rearrangement chemistry of propargylic ester has been developed. Most probably, under platinum catalysis, propargylic ester undergoes the 1,3-acyloxy migration to afford metal allene intermediate, which is followed by the Diels-Alder-type reaction. 1,3-Acyloxy migration is the key step during the transformation.

MeSH terms

  • Alkynes / chemical synthesis
  • Alkynes / chemistry*
  • Catalysis
  • Cyclization
  • Esters / chemical synthesis*
  • Esters / chemistry
  • Molecular Structure
  • Platinum / chemistry*
  • Propanols / chemical synthesis*
  • Propanols / chemistry
  • Stereoisomerism

Substances

  • Alkynes
  • Esters
  • Propanols
  • Platinum
  • propargyl alcohol