Abstract
New manzamine alkaloids, zamamidines A (1) and B (2), have been isolated from an Okinawan marine sponge Amphimedon species. The structures and stereochemistry of 1 and 2 were elucidated from the spectroscopic data and conformational analysis. Zamamidines A (1) and B (2) are the first manzamine alkaloids possessing a second beta-carboline ring via an ethylene unit at N-2 of manzamine H and 1,2,3,4-tetrahydromanzamine B, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Animals
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Carbazoles / chemistry*
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Carbazoles / isolation & purification
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Crystallography, X-Ray
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Heterocyclic Compounds, 4 or More Rings / chemistry*
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Heterocyclic Compounds, 4 or More Rings / isolation & purification
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Porifera / chemistry*
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Species Specificity
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Stereoisomerism
Substances
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Alkaloids
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Carbazoles
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Heterocyclic Compounds, 4 or More Rings
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zamamidine A
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zamamidine B