Abstract
The histopathologic presence of a cornoid lamella is often associated with a diagnosis of porokeratosis. However, this feature is not pathognomonic for porokeratosis and can be found in a number of other dermatologic conditions, which include seborrheic keratosis, verruca vulgaris, actinic keratosis, squamous-cell carcinoma in situ, basal-cell carcinoma, milia, and scar. Notably, the etiology of none of these entities is inflammatory. Wade and Ackerman consider cornoid lamellation to be a distinctive histopathologic reaction pattern that reflects the disordered progression of epidermal cells during cornification. As such, this pattern is not specific for any given disease process. We report a case in which the lesions appeared inflammatory clinically as well as histopathologically, did not resemble porokeratosis despite the presence of cornoid lamellae, and responded to topical glucocorticoids.
MeSH terms
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Anti-Inflammatory Agents / therapeutic use
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Antiviral Agents / therapeutic use
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Diagnosis, Differential
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Facial Dermatoses / classification
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Facial Dermatoses / diagnosis
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Facial Dermatoses / drug therapy
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Facial Dermatoses / pathology*
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Glucocorticoids / therapeutic use
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Hepatitis C / drug therapy
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Humans
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Inflammation
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Interferon alpha-2
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Interferon-alpha / therapeutic use
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Male
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Middle Aged
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Polyethylene Glycols
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Porokeratosis / diagnosis
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Recombinant Proteins
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Scalp Dermatoses / classification
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Scalp Dermatoses / diagnosis
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Scalp Dermatoses / drug therapy
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Scalp Dermatoses / pathology*
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Skin Diseases, Papulosquamous / classification
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Skin Diseases, Papulosquamous / diagnosis
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Skin Diseases, Papulosquamous / drug therapy
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Skin Diseases, Papulosquamous / pathology*
Substances
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Anti-Inflammatory Agents
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Antiviral Agents
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Glucocorticoids
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Interferon alpha-2
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Interferon-alpha
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Recombinant Proteins
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Polyethylene Glycols
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peginterferon alfa-2b