Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider

Takahiro Nishimaru; Masako Sano; Yoshihiro Yamaguchi; Tateaki Wakamiya

doi:10.1016/j.bmc.2008.11.029

Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider

Bioorg Med Chem. 2009 Jan 1;17(1):57-63. doi: 10.1016/j.bmc.2008.11.029. Epub 2008 Nov 19.

Authors

Takahiro Nishimaru¹, Masako Sano, Yoshihiro Yamaguchi, Tateaki Wakamiya

Affiliation

¹ Faculty of Science and Technology, Kinki University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.

PMID: 19062295
DOI: 10.1016/j.bmc.2008.11.029

Abstract

Acylpolyamine-type spider toxins are known to be potent and specific blockers against glutamate receptors (GluRs). The present study describes the syntheses and biological activities of several fluorescent-labeled analogs related to a Madagascar Joro spider toxin NPTX-594 to analyze visually the unknown interaction between spider toxins and GluRs.

MeSH terms

Animals
Excitatory Amino Acid Antagonists / chemical synthesis*
Fluorescent Dyes*
Polyamines / chemical synthesis*
Polyamines / pharmacology
Receptors, Glutamate / drug effects
Spider Venoms / chemical synthesis*
Spider Venoms / pharmacology

Substances

Excitatory Amino Acid Antagonists
Fluorescent Dyes
JSTX spider toxin
Polyamines
Receptors, Glutamate
Spider Venoms