Host interception of bacterial communication signals

Alexander R Horswill; William M Nauseef

doi:10.1016/j.chom.2008.11.003

Host interception of bacterial communication signals

Cell Host Microbe. 2008 Dec 11;4(6):507-9. doi: 10.1016/j.chom.2008.11.003.

Authors

Alexander R Horswill¹, William M Nauseef

Affiliation

¹ Department of Microbiology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. [email protected]

PMID: 19064249
DOI: 10.1016/j.chom.2008.11.003

Abstract

Pathogenic Staphylococcus aureus employs a cell-to-cell communication system to control virulence factor expression in the host during infection. In this issue, Peterson et al. (2008) report that host lipoproteins can sequester the S. aureus communication signal and antagonize virulence factor expression and pathogenesis in a murine model of infection.

Publication types

Comment

MeSH terms

Animals
Bacterial Proteins / antagonists & inhibitors*
Lipoproteins / immunology*
Mice
Peptides, Cyclic
Staphylococcal Infections / immunology*
Staphylococcus aureus / pathogenicity*

Substances

AgrD protein, Staphylococcus
Bacterial Proteins
Lipoproteins
Peptides, Cyclic

Abstract

Publication types

MeSH terms

Substances

Grants and funding