Abstract
3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / antagonists & inhibitors*
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Benzamides / chemistry
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Benzamides / pharmacology*
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Cytoskeletal Proteins / antagonists & inhibitors*
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Microbial Sensitivity Tests
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Staphylococcus / drug effects*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Benzamides
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Cytoskeletal Proteins
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FtsZ protein, Bacteria
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3-methoxybenzamide