A review of literature was conducted on farm and ranch population estimates, the prevalence of disability in that group, and the effect of disease and injury on that disability rate. Methods used by various entities (primarily governmental) to estimate the population and disability prevalence among farmers, ranchers, family members, and other agricultural workers are summarized. A systematic methodology was developed to combine results from the most recent surveys and censuses and was used to make best estimates of the agricultural population impacted by disability. The findings show that estimates of the disability population in the farm, ranch, and agricultural labor sector, ranges from 1.04 million to 2.23 million individuals depending upon which surveys and censuses are used. Primary reasons identified for the inability to provide a more precise population size include lack of consistent survey methodologies and definitions. A strong argument can be made for additional efforts to determine a more accurate value for the number of individuals in the farm and ranch population who would benefit from disability services, as well as a more accurate estimate of the total population directly involved in agricultural production. Without such data, calculation of more reliable exposure levels to injury and disability is not possible.