Intramedullary amputation neuromas associated with spinal ependymomas

Am J Surg Pathol. 2009 Apr;33(4):639-43. doi: 10.1097/PAS.0b013e31818fe3c9.

Abstract

We report 5 spinal intramedullary masses containing combined ependymoma and traumatic neuroma. The ependymomas, grade II "cellular" types, were intermixed with or separate from wavy, vaguely fascicular tissue that contained multiple axons immunoreactive for neurofilament protein. The neuromas presumably arose from small perivascular nerve twigs that have been implicated in the pathogenesis of intramedullary neuromas in non-neoplastic spinal diseases. Pathologists should be aware of this distinctive intramedullary tissue that is not to be confused with a neoplasm.

MeSH terms

  • Adolescent
  • Aged
  • Biomarkers, Tumor / analysis
  • Ependymoma / chemistry
  • Ependymoma / pathology*
  • Ependymoma / surgery
  • Female
  • Glial Fibrillary Acidic Protein / analysis
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary
  • Neuroma / chemistry
  • Neuroma / pathology*
  • Neuroma / surgery
  • S100 Proteins / analysis
  • Spinal Cord / pathology
  • Spinal Neoplasms / chemistry
  • Spinal Neoplasms / pathology*
  • Spinal Neoplasms / surgery

Substances

  • Biomarkers, Tumor
  • Glial Fibrillary Acidic Protein
  • S100 Proteins