Abstract
Pinacidil, a potassium-channel opener, inhibited the ryanodine-sensitive oscillatory outward potassium current induced by Ca released from an intracellular store. Glibenclamide, a blocker of the ATP-sensitive K-channel, prevented the action of pinacidil, suggesting the presence of an additional site (to K channels) for the vasodilator actions of pinacidil at which glibenclamide can act as an antagonist.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / pharmacology
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Animals
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Calcium / physiology
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Glyburide / pharmacology*
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Guanidines / antagonists & inhibitors
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Guanidines / pharmacology*
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In Vitro Techniques
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / metabolism*
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Pinacidil
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Portal Vein / drug effects
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Portal Vein / metabolism
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Potassium Channels / drug effects*
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Rabbits
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Ryanodine / antagonists & inhibitors*
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Vasodilator Agents / pharmacology*
Substances
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Guanidines
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Potassium Channels
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Vasodilator Agents
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Ryanodine
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Pinacidil
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Adenosine Triphosphate
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Glyburide
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Calcium