We present a case of 60 years old patient with the history of repeated sinusitis and bronchial asthma, who developed Churg-Strauss syndrome (CSS) with mono-neuritis multiplex, skin laesions on the head and acute perimyocarditis, which led to suspicion on myocardial infarction. Diagnosis of CSS was based on clinical manifestations, blood hypereosinophilia and histological examination of nasal mucous membrane biopsy. Subsequent immunosuppressive therapy led to regression of symptoms and improvement of temporarily decreased left ventricular function.