3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

Robert T Hendricks; Stacey R Spencer; James F Blake; Jay B Fell; John P Fischer; Peter J Stengel; Vincent J P Leveque; Sophie Lepogam; Sonal Rajyaguru; Isabel Najera; John A Josey; Steven Swallow

doi:10.1016/j.bmcl.2008.11.060

3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

Bioorg Med Chem Lett. 2009 Jan 15;19(2):410-4. doi: 10.1016/j.bmcl.2008.11.060. Epub 2008 Nov 20.

Authors

Robert T Hendricks¹, Stacey R Spencer, James F Blake, Jay B Fell, John P Fischer, Peter J Stengel, Vincent J P Leveque, Sophie Lepogam, Sonal Rajyaguru, Isabel Najera, John A Josey, Steven Swallow

Affiliation

¹ Roche Palo Alto LLC, Medicinal Chemistry, 3431 Hillview Avenue, MS: R6E-3 (R6W-120B), Palo Alto, CA 94304, USA. [email protected]

PMID: 19070486
DOI: 10.1016/j.bmcl.2008.11.060

Abstract

Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Isoquinolines / chemistry
Isoquinolines / pharmacology*
Models, Molecular
RNA-Dependent RNA Polymerase / antagonists & inhibitors*
Structure-Activity Relationship
Viral Nonstructural Proteins / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Isoquinolines
Viral Nonstructural Proteins
NS-5 protein, hepatitis C virus
RNA-Dependent RNA Polymerase